南京医科大学基础医学院李砚川课题组诚聘博士、博士后及科研助理

PI简介

李砚川，南京医科大学基础医学院细胞生物学系教授，博士生导师。长期从事重要信号转导通路在 B 细胞命运决定和免疫应答中的分子机理研究，已发表 16 篇国际权威期刊学术论文，其中近 5 年以第一作者或兼通讯作者发表 3 篇学术论文（Blood，2021；Cell Research，2019；JEM，2023）以及 13 篇共同第一或共同作者文章（包括 Nature Cell Biology，2篇；Nature Medicine；Nature Immunology；Gastroenterology；Journal of Pineal Research；Nature Communications；ScienceAdvances；Cell Reports；PNAS等）。代表性论文多次得到国际生物医学评论机构Faculty Opinions（原 F1000）专家撰写专文推荐，并被 Nature 等权威期刊广泛引用。目前担任 Nucleic AcidsResearch，Molecular Therapy，Protein ＆ Cell 等多个高水平学术期刊特邀评审人。

教育背景及工作经历：

2012-2016年，北京协和医学院博士

2016-2021年，美国德克萨斯大学MD安德森癌症中心博士后

2021-2022年，美国德克萨斯大学MD安德森癌症中心研究科学家

2022-2023年，美国贝勒医学院副研究员

2023-至今年，南京医科大学教授

近5年代表性论文（通讯作者*）：

1.Li, Yanchuan, Xiaoping Xie, ZuliangJie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, SungYun Jung, Natalia Baran, Marina Y Konopleva, Xuhong Cheng, Shao-Cong Sun*. DYRK1a mediates BAFF-induced noncanonical NF-κB activation topromote autoimmunity and B cell leukemogenesis.Blood, (2021) 138 (23): 2360–2371.

2.Yanchuan Li,Jin-Young Yang, Xiaoping Xie, Zuliang Jie, Lingyun Zhang, Jianhong Shi, DanielLin, Meidi Gu, Xiaofei Zhou, Haiyan S Li, Stephanie S Watowich, Antrix Jain,Sung Yun Jung, Jun Qin, Xuhong Cheng, Shao-Cong Sun*. Preventing Abnormal NF-κB Activation and Autoimmunity byOtub1-Mediated p100 Stabilization. Cell research 29, no. 6 (2019): 474.

3.Yanchuan Li*, LeleZhu, Chun-Jung Ko, Jin-Young Yang, Ganiraju Manyam, Jing Wang, Xuhong Cheng, ShuliZhao*, Zuliang Jie*. TRAF3-EWSR1 signaling axis acts as a checkpoint ongerminal center responses. Journal of experimental medicine,(2023) 220 (8): e20221483

4.Lele Zhu, Yanchuan Li, Xiaoping Xie, Xiaofei Zhou, Meidi Gu, ZuliangJie, Chun-Jung Ko, Tianxiao Gao, Blanca E Hernandez, Xuhong Cheng, Shao-CongSun*. TBKBP1 and TBK1 form a growth factor signalling axis mediatingimmunosuppression and tumourigenesis. Nature cell biology, (2019), 21(12): 1604-1614.

5.Lingyun Zhang, Chun-Jung Ko, Yanchuan Li, Zuliang Jie, Lele Zhu,Xiaofei Zhou, Xiaoping Xie, Tianxiao Gao, Ting Liu, Xuhong Cheng, Shao-Cong Sun*.Peli1 facilitates NLRP3 inflammasome activation by mediating ASCubiquitination. Cell reports 37, no. 4 (2021):109904.

6.Jin-Young Yang, Zuliang Jie, AmberMathews, Xiaofei Zhou, Yanchuan Li,Meidi Gu, Xiaoping Xie, Chun-Jung Ko, Xuhong Cheng, Yuan Qi, Jeannelyn SEstrella, Jing Wang, Shao-Cong Sun*. Intestinal epithelial TBK1 preventsdifferentiation of T-helper 17 cells and tumorigenesis in mice. Gastroenterology 159, no. 5 (2020): 1793-1806.

7.Zuliang Jie, Chun-Jung Ko, HuiWang, Xiaoping Xie, Yanchuan Li,Meidi Gu, Lele Zhu, Jin-Young Yang, Tianxiao Gao, Wenjuan Ru, Shao-Jun Tang,Xuhong Cheng, Shao-Cong Sun*. Microglia promote autoimmune inflammation via thenoncanonical NF-κB pathway. Science advances 7, no. 36(2021): eabh0609.

8.Zhu, Lele*, Xiaofei Zhou, Meidi Gu,Jiseong Kim, Yanchuan Li,Chun-Jung Ko, Xiaoping Xie, Tianxiao Gao, Xuhong Cheng, Shao-Cong Sun*. Dapl1 controls NFATc2 activation toregulate CD8+ T cell exhaustion and responses in chronic infection and cancer. Nature cell biology 24, no. 7 (2022): 1165-1176.

9.Zuliang Jie, Jin-Young Yang, MeidiGu, Hui Wang, Xiaoping Xie, Yanchuan Li,Ting Liu, Lele Zhu, Jianhong Shi, Lingyun Zhang, Xiaofei Zhou, Donghyun Joo,Hans D Brightbill, Yingzi Cong, Daniel Lin, Xuhong Cheng, Shao-Cong Sun*. NIKsignaling axis regulates dendritic cell function in intestinal immunity andhomeostasis. Nature immunology 19, no. 11 (2018):1224-1235.

10.Gao, Tianxiao, Ting Liu, Chun-JungKo, Lingyun Zhang, Donghyun Joo, Xiaoping Xie, Lele Zhu, Yanchuan Li, Xuhong Cheng, Shao-Cong Sun*. Myeloid cell TBK1 restrictsinflammatory responses. Proceedings of theNational Academy of Sciences 119, no. 4 (2022): e2107742119.